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| Set | Card | | Card Description | |
| 1967 Topps | 536 | | Cubs Rookies Niekro, Joe (Chicago Cubs ) RC Popovich, Paul (Chicago Cubs ) |
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| 1968 Topps | 475 | | Niekro, Joe (Chicago Cubs ) |
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| 1969 Topps | 43 | | Niekro, Joe (Chicago Cubs ) |
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| 1970 Topps | 508 | | Niekro, Joe (Detroit Tigers ) |
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| 1971 Topps | 695 | | Niekro, Joe (Detroit Tigers ) |
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| 1972 Topps | 216 | | Niekro, Joe (Detroit Tigers ) |
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| 1973 Topps | 585 | | Niekro, Joe (Detroit Tigers ) |
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| 1974 Topps | 504 | | Niekro, Joe (Atlanta Braves ) |
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| 1975 Topps | 595 | | Niekro, Joe (Atlanta Braves ) |
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| 1976 Topps | 273 | | Niekro, Joe (Houston Astros ) |
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| 1977 Topps | 116 | | Niekro, Joe (Houston Astros ) |
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| 1978 Topps | 306 | | Niekro, Joe (Houston Astros ) |
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| 1979 Topps | 68 | | Niekro, Joe (Houston Astros ) DP |
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| 1980 Topps | 205 | | Victory Leaders Flanagan, Mike (Baltimore Orioles) LL Niekro, Joe (Houston Astros ) LL Niekro, Phil (Atlanta Braves ) LL |
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| 1980 Topps | 437 | | Niekro, Joe (Houston Astros ) |
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| 1981 Fleer | 54 | | Niekro, Joe (Houston Astros ) |
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| 1981 Donruss | 380 | | Niekro, Joe (Houston Astros ) |
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| 1981 Topps | 722 | | Niekro, Joe (Houston Astros ) |
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| 1982 Donruss | 167 | | Niekro, Joe (Houston Astros ) |
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| 1982 Fleer | 221 | | Niekro, Joe (Houston Astros ) |
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